Hemophilia :: essays research papers

Hemophilia is a rargon brokertic blood change state pain that primarily affects males. People living with haemophilia do non rescue enough of, or are missing, one of the blood clotting proteins by nature found in blood. Two of the most common forms of hemophilia are A and B. In persons with hemophilia A (also called classic hemophilia), clotting means VIII is non birth in sufficient amounts or is absent. In persons with hemophilia B (also called Christmas disease), clotting factor IX is not present in sufficient amounts or is absent. People with hemophilia do not bleed more profusely or bleed faster than standard they bleed for a longer period of time.Virtually all citizenry who have hemophilia A or B are born(p) with it. The majority of people with hemophiliahave a family history (it is a hereditary disorder).In as many as 30% of cases, thither is no family history of hemophilia. In these cases, the mother whitethorn not be aware that she carries the gene for hemophilia, or a gene mutation may have occurred spontaneously.A long historyHemophilia was identified as early as biblical times. Doctors in medieval times were known with it as well. In 1803, a Philadelphia doctor published the first description of hemophilia in the United States.But it was not until 30 age later that hemophilia became widely recognized. Hemophilia laterdeveloped a reputation as the "royal disease" because it passed from Queen Victoria of England to her posterity throughout the royal houses of Europe.Who Gets Hemophilia?Hemophilia occurs when the gene to produce clotting factor does not work correctly.Without the proper amount of clotting factor, release occurs easily.Hemophilia is an inherited disorder in about two thirds of the cases. close to one third ofthe cases of hemophilia occur due to spontaneous changes in the gene or mutations. The presence of a mutated gene may not be noted until a woman with no family history of hemophilia has a son with the disord er.The gene for hemophilia is carried on the X chromosome. The gene for hemophilia isalso recessionary. This is why hemophilia is referred to as an X-linked recessive disorder.If in that respect is not a normal gene present to offset the defective, recessive gene, thedisorder will be present. Whether or not a nipper will have hemophilia or be a carrier wave forthe disorder depends on the status of the mother and of the father. The figure belowshows how this typesetters case of disorder is inherited.